发给老马备查:& H8 }% R/ O) k. ^, I
滴水察海(69304838) 15:23:23
: E0 j, T; t5 v7 b' U# [4 U+ B# Q老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱; M: f9 b; z- Y9 s; U! ?
吉非替尼和S-1连用的依据
2 ~9 c; @* b; M) \Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
0 s: Z! ?# g. z m. M0 r是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
% }; s8 |# z9 s# S4 h- ?+ V这样是不是推理出,耐药后,可以用S-1和培美了?: z% |5 x, A, @# p: Z: Y
结论:3 J- t+ A' x: w# W. }6 P& U% L; g
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |