发给老马备查:) J, P" [- ^' T/ l
滴水察海(69304838) 15:23:23
8 J4 M- S% Y x7 n7 }; m老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱0 m2 ]6 i! b, B G, i+ `0 R
吉非替尼和S-1连用的依据
3 h d* P i) ], V! |Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.% D3 m, F X0 ^4 [! y. v: K7 u
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达% S* ?- E; U- F* K1 k9 z
这样是不是推理出,耐药后,可以用S-1和培美了?
, Y5 {: _, Z3 D$ {结论:
! ?- \( W# R) @+ z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |