发给老马备查:
% f* o* J0 Q+ [8 D9 T P6 W, @' Y/ H滴水察海(69304838) 15:23:23
; q) D+ J( p* s7 {# H老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
. p/ F2 p, Q7 b7 a# M' \1 |. O吉非替尼和S-1连用的依据: R/ t- H& ^4 Z
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.# H5 f( t! c4 x$ n
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达( a) {3 Q d, v7 b. {
这样是不是推理出,耐药后,可以用S-1和培美了?
/ A- I2 y$ I& \# d+ p" ]# M结论: ^ X6 s' e _, C% G
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |