发给老马备查:$ c) I l& Y8 W& {3 s# J
滴水察海(69304838) 15:23:23 t( s0 h8 ^, B6 s
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
% V1 v0 |9 E# O8 G- G* z! S吉非替尼和S-1连用的依据
/ ^3 l J. n2 s e, a; I7 |Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
9 C* z. m' L" y0 F0 V" Q$ _是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
' V3 M6 _0 [( n! b! ?. x3 x这样是不是推理出,耐药后,可以用S-1和培美了?% T4 k) P& |+ G3 `4 X$ h
结论:
, _6 A6 F& g) q8 C如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |