平安! 发表于 2011-11-9 19:57
$ Q+ B, `6 T, J0 M) yPazopanib (100 mg/kg/day free base equivalent) 2 e4 u, f4 \6 L+ S. r3 ]2 u& j
这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。
( g6 |/ N. e: v5 C搜索了一下,原料一大堆。% ], s; U: H, c/ \3 i1 l$ N' C* {
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对不起!100mg/kg是用于移植瘤的,我弄错了。6 e2 q4 |8 f, V" O+ `, K: t
. S, i* a4 g# r以下是正版说明书的推荐用量。
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8 ]1 u* w/ y2 q" O--------------------- DOSAGE AND ADMINISTRATION ----------------: e& V4 [# _6 o$ Q8 ]
* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1)
! ]( S( v7 I- N* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) . K' U4 a) L# ?9 Q7 X
---------------------DOSAGE FORMS AND STRENGTHS --------------" m5 y2 T4 |. c. r8 P( ^: h
200 mg tablets. (3)
+ p+ n, k. G0 V4 p4 F-------------------------------CONTRAINDICATIONS------------------------ |