看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. 9 ?2 B" Z; d$ @8 Q* b
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k/ v9 R& [1 f6 ]# c5 s, pCombination Feasibility according to preliminary data
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) A) }* o( O; |Bevacizumab + sorafenib Yes, reduced dose # m F N% y N2 f
Bevacizumab + sunitinib† No ! b9 H) t+ M0 H$ f; w$ Q% R
Bevacizumab + temsirolimus Yes 8 @, C1 X9 S5 y/ c. c, ^/ r
Bevacizumab + everolimus Yes
0 s- b, P; s' c7 FSorafenib + sunitinib ? , f" i$ Q( j/ r+ ~
Sorafenib + temsirolimus Yes, reduced dose * @8 Q# y9 C% u& ~& u
Sorafenib + everolimus Yes, reduced dose
7 A% C, ?4 O \ j1 {% l) Q) j! XSunitinib + temsirolimus† No " i2 S" Y O5 r2 W
Sunitinib + everolimus ? * Z& p c* S u
Temsirolimus + everolimus ?
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" [* S# t' ^4 r3 w* N†Led to US FDA warning.
V3 Y9 J/ ]$ y4 Z?: As yet unattempted combination., Z2 ^/ b2 c7 F6 A5 m/ V
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